Terms of Use

Access to and use of this website are subject to the following conditions. Please do not use this website unless you agree with these conditions.

This website has been developed by and is administered by Adapt Pharma Canada Ltd (“Adapt Pharma”). We reserve the right to discontinue or to make partial or complete modifications to this website. Please note that we may make such changes at our own discretion and without prior announcement. We encourage you to visit frequently to stay informed about these terms of use.

Regulations for product use are established by country. Information contained on this website pertains only to Canada, and is not intended to provide adequate information for product use. Before using any product, read and carefully observe the label directions.

TRADEMARKS AND COPYRIGHTS

All details, documents and illustrations published on this website are the sole property of Adapt Pharma, Inc.. Any permission to use the same is granted on the provision that the relevant copyright note is displayed on all copies, that such details are only used for personal purposes, that they are not exploited commercially, that the details are not modified in any way and that all illustrations gained from the website are only used in conjunction with the accompanying text.

All material found on this web site (“Information”) is protected under the copyright laws of Canada and of other countries. Certain names, words, titles, phrases, logos, icons, graphics or designs in the pages of this website may constitute trade names, trademarks or service marks of Adapt Pharma, Inc. its subsidiaries, affiliates, licensors or joint venture partners or the use of which may have been licensed to them. Any unauthorized use or abuse of these materials including copyright, trade names, trademarks or service marks posted on this website, may violate federal, common or civil law trademark law and copyright law, and may result in legal action. Unauthorized use shall include without limitation, use in connection with any product or service that is not related to Adapt Pharma or Adapt Pharma, Inc., in any manner that is likely to cause confusion among customers, or in any manner that disparages or discredits Adapt Pharma and or any of its affiliated entities or the owner of the mark.

The trademarks, logos and service mark (collectively, the "Trademarks") displayed on this website are registered and unregistered trademarks owned or licensed by Adapt Pharma. In particular, NARCAN is a registered trademark licensed to ADAPT Pharma Operations Limited. Nothing on this website should be construed as granting, by implication or otherwise, any license or right in or to the Trademarks without the express written permission of Adapt Pharma or such third party. In addition, any reproduction, retransmission or use of this website's contents for other than personal, non-commercial purposes requires the prior written consent of Adapt Pharma.

The following copyright notice must appear on every copy of the contents of this site or a portion thereof: "Copyright © 2017 Adapt Pharma, Inc. 100 Matsonford Road, Building 4, Suite 201, Radnor, PA 19087. All rights reserved".

Permission to use the Information is granted, provided that (1) the above copyright notice appears on all copies; (2) use of the Information is for informational and non-commercial or personal use only; (3) the Information is not modified in any way; and (4) no graphics available from this Internet site are used separate from accompanying text.

EXCLUSION OF LIABILITY

Your use of this Site is at your own risk and in no event will Adapt Pharma or its officers, directors or employees, suppliers or contributors to this site be liable for any damages, including without limitation, direct or indirect, special, punitive, exemplary, incidental, moral or consequential damages, loss of profits, opportunities or information, damages for business interruption or loss of programs or other data on your information handling system or for other expenses arising out of or in connection with the website, with any software algorithms available thereon or with any hyperlinked web site or for use thereof or inability to use by interruption, defect, delay in operation or transmission, computer virus, worms, Trojan horses or other items of a destructive nature or line or system failure, even if Adapt Phama is advised of the possibility of such damages, losses or expenses. Software algorithms made available and hyperlinks to other internet resources are at your own risk; the content, accuracy, opinions expressed, and other links provided by these software algorithms and resources are not investigated, verified, monitored, or endorsed by Adapt Pharma. FOR GREATER CERTAINTY, THIS EXCLUSION OF LIABILITY APPLIES TO ANY AND ALL NEGLIGENCE OF ADAPT PHARMA OR ANY OF ITS DIRECTORS, OFFICERS OR EMPLOYEES OR OF ANY SUPPLIER OR CONTRIBUTOR TO THIS SITE.

Adapt Pharma tries to ensure that all information is as complete and accurate as reasonably possible at the time of its posting on the Web site. Adapt Pharma does not, however, give any warranty whatsoever with respect to such material. Specifically, Adapt Pharma gives no warranty including as to the accuracy, timeliness, completeness, merchantability or fitness for any particular purpose, or non-infringement of an intellectual property right with respect to any information, graphics and/or other material available through the website and disclaims any liability for failure to update the website for errors or omissions in the content of the site. Some jurisdictions do not allow the exclusion of implied warranties, so the above exclusion may not apply to you.

Information on the website may contain technical inaccuracies or typographical errors. Information may be changed or updated without notice. Adapt Pharma may also make improvements and/or changes in the services and/or the programs described in this information at any time without notice.

You agree to indemnify, contribute to and hold harmless Adapt Pharma, its subsidiaries, affiliates, contractors, agents, officers, directors and/or employees, against any liability, be it civil, criminal or quasi-criminal, resulting from your use of the website REGARDLESS OF WHETHER NEGLIGENCE OF ADAPT PHARMA, ITS SUBSIDIARIES, AFFILIATES, CONTRACTORS, AGENTS, OFFICERS, DIRECTORS AND/OR EMPLOYEES, MAY HAVE CAUSED OR CONTRIBUTED THERETO. You shall be responsible to the full extent of any liability, payment or other agreement made by Adapt Pharm, its subsidiaries, affiliates, contractors, agents, officers, directors and/or employees, in settlement and/or satisfaction of any claim or potential claim, whether such payment or agreement is made or concluded prior to or following the institution of formal proceedings against Adapt Pharma, its subsidiaries, affiliates, contractors, agents, officers, directors and/or employees.

LINKS TO OTHER SITES

The website contains links to facilitate your access to third party sites. Adapt Pharma does not control any third party site and is not responsible for the contents of any linked site or any link contained in a linked site. Adapt Pharma is providing such link to you only as a convenience and the inclusion of any link does not imply endorsement, investigation or verification by Adapt Pharma of the linked site or information contained therein.

INTERNATIONAL USERS

This website is exclusively intended for use in Canada. Adapt Pharma gives no guarantee that the details presented on this website are also correct in places outside Canada, and, in particular, that products and services will be available with the same appearance, in the same sizes or on the same conditions. Should you call up this website from a place outside Canada or download contents from such a place, please note that it is your own responsibility to ensure that you act in compliance with local legislation applicable in that place.

Products mentioned on this website may come in different packaging, in different package sizes, or with different lettering or markings, depending on the country.

APPLICABLE LAW

The laws of the Province of Ontario will govern these disclaimers, terms, and conditions, without giving effect to any principles of conflicts of laws. We reserve the right to make changes to our site and these disclaimers, terms, and conditions at any time.

Serious Warnings and Precautions

  • Before administering NARCAN™ Nasal Spray, call 911 for emergency medical help. Do this immediately if you suspect or are aware of an opioid overdose.
  • Make sure to watch the person who received NARCAN™ Nasal Spray. You may need to give additional doses of NARCAN™ Nasal Spray until emergency medical help arrives.
  • You may need to help the person who received NARCAN™ Nasal Spray. The patient may have a reaction such as becoming aggressive, shaking and/or vomiting. You will need to pay special attention when giving NARCAN™ Nasal Spray to a newborn who is less than four weeks old or a pregnant woman. Some of these reactions can be life-threatening for a newborn or a fetus.

Indications and Clinical Use

NARCAN™ Nasal Spray is a pure opioid antagonist indicated for emergency use outside of a hospital to reverse known or suspected opioid overdose, as manifested by respiratory and/or severe central nervous system depression.

NARCAN™ Nasal Spray can be administered by a bystander (non-healthcare professional) before emergency medical assistance becomes available, but it is not intended to be a substitute for professional medical care. Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before administering naloxone.

Contraindications

  • Patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container.

Most Serious Warnings & Precautions

  • Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before using naloxone.
  • Individuals with a satisfactory response to an initial dose of naloxone should be kept under continued surveillance.
  • Caregivers administering naloxone should be prepared to act in response to or assist the patient in cases of potential adverse reactions such as aggressive reactions, convulsions and vomiting. Special attention is warranted if naloxone is administered to a neonate or a pregnant woman.

Other Relevant Warnings and Precautions

  • In opioid dependent people, naloxone may trigger an acute opioid withdrawal syndrome
  • Rebound opioid toxicity, including respiratory depression, following the temporary reversal of the opioid overdose
  • Not effective against respiratory depression due to non-opioid drugs
  • Rare cases of cardiac arrest, tachycardia and ventricular fibrillation
  • Post-operative consideration: instances of hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema and rare cases of cardiac arrest have been reported. Death, coma, and encephalopathy have been reported as sequelae of these events
  • Rare cases of convulsions or seizures
  • Irritability and aggressive behaviour
  • Gastrointestinal reactions including diarrhea, nausea, vomiting and abdominal cramps
  • Use in nursing women has not been established

For More Information:

Please consult the product monograph at http://narcannasalspray.ca/pdf/NARCAN-Product-Monograph-ca-en.pdf for important information relating to contraindications, adverse reactions, drug interactions, patient selection, and dosing information which have not been discussed in this piece.

The product monograph is also available by calling 1-844-898-0657.

Please see full Product Information including the Patient Information for NARCAN™ Nasal Spray.

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References

1 World Health Organization. “Management of Substance Abuse: Information sheet on opioid overdose.” November 2014. http://www.who.int/substance_abuse/information-sheet/en/ Accessed March 1, 2017.

2 Ontario College of Pharmacists. “Dispensing or Selling Naloxone: Guidance for pharmacy professionals when dispensing or selling naloxone as a Schedule II drug.” February 9, 2017. http://www.ocpinfo.com/library/practice-related/download/Naloxone.pdf Accessed March 1, 2017.

3 NARCAN™ Nasal Spray Product Monograph. Adapt Pharma Operations Limited, March 24, 2017.

4 Howlett, K et al. “How Canada got addicted to fentanyl.” Globe and Mail, January 5, 2017. http://www.theglobeandmail.com/news/investigations/a-killer-high-how-canada-got-addicted-tofentanyl/article29570025/ Accessed January 10, 2017.

5 National Institutes of Health, PubChem Open Chemistry Database, Carfentanil, Available at: https://pubchem.ncbi.nlm.nih.gov/compound/carfentanil#section=Top Accessed on January 20, 2017.

6 Harm Reduction Coalition. “Overdose FAQs.” http://harmreduction.org/issues/overdose-prevention/overview/overdose-faqs/ Accessed January 11, 2017.

7 Government of Canada. “Opioids.” http://healthycanadians.gc.ca/healthy-living-vie-saine/substance-abus…icomanie/prescription-abuse-abus-ordonnance/opiods-opiodes-eng.php#a2 Accessed Jan 9, 2017.

8 Government of Canada. “Opioids.” Available at: https://www.canada.ca/en/health-canada/services/substance-abuse/prescription-drug-abuse/opioids.html Accessed January 25, 2017.

Distributed by Adapt Pharma Canada Ltd. Mississauga, ON L5N 6A6 CANADA

© 2017 ADAPT Pharma Canada Ltd. NARCAN is a trademark licensed to ADAPT Pharma Operations Limited.

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